Ribosomal protein S19

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[[Image:RPS19.png|left|200px|thumb|Crystal Structure of Ribosomal protein S19 from [[2zm6]], chain S]]
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<StructureSection load='2v7f' size='350' side='right' scene='' caption='Ribosomal protein S19 complex with Cl- ion (PDB code [[2v7f]])'>
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{{STRUCTURE_2zm6| PDB=2zm6 | SIZE=400| SCENE=Ribosomal_protein_S19/Cv/1 |right|CAPTION=Ribosomal protein S19 from [[2zm6]], chain S }}
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== Function ==
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[[Ribosomal protein S19]] (RPS19) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S19/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It forms a complex with RPS13 that binds to 16S RRNA<ref>PMID:8722009</ref>.
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[[Ribosomal protein S19]] (RPS19) is one of the 22 proteins which belong to the <scene name='Ribosomal_protein_S19/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. It forms a complex with RPS13 that binds to 16S RRNA. The images at the left and at the right correspond to one representative RPS19, ''i.e.'' the crystal structure of Ribosomal protein S19 from ''Thermus thermophilus'' ([[2zm6]], chain S).
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{{TOC limit|limit=2}}
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== Relevance ==
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RPS19 is a potent anti-inflammatory agent which appears to work primarily by inhibiting MIF signaling<ref>PMID:23252627</ref>.
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</StructureSection>
== 3D Structures of Ribosomal protein S19 ==
== 3D Structures of Ribosomal protein S19 ==
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''Update July 2012''
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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===S19===
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[[2v7f]] – RPS19 – ''Pyroccocus abyssi''<br />
[[2v7f]] – RPS19 – ''Pyroccocus abyssi''<br />
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[[1qkh]], [[1qkf]] - TtRPS19 - ''Thermus thermophilus'' – NMR
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[[1qkh]], [[1qkf]] - TtRPS19 - ''Thermus thermophilus'' – NMR<br />
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[[3a1p]] – TtRPS19 + ribosome maturation factor<br />
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=== S19 in small ribosomal subunit ===
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[[2zm6]], [[1n36]], [[1j5e]], [[3oge]], [[3ogy]], [[3ohc]], [[3ohd]], [[3ohy]], [[3oi0]], [[3oi2]], [[3oi4]], [[3oto]] - TtRPS19 in 30S ribosomal subunit+THX+16S RRNA - ''Thermus thermophilus''<br />
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[[2vqe]], [[2vqf]], [[2uuc]], [[2e5l]], [[2uu9]], [[2uua]], [[2uub]], [[3pyn]], [[3pyq]], [[3pys]], [[3pyu]] - TtRPS19 in 30S ribosomal subunit+16S RRNA+RNA fragment<br />
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[[3kc4]] – EcRPS19 in 30S ribosomal subunit – ''Escherichia coli''<br />
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[[3i1m]], [[3i1o]], [[3df1]], [[3df3]], [[2vho]], [[2vhp]], [[2avy]], [[2aw7]], [[1pnx]], [[3ofa]], [[3ofb]], [[3ofx]], [[3ofy]], [[3ofo]], [[3ofp]], [[3or9]], [[3ora]], [[3oaq]], [[3oar]] - EcRPS19 in 30S ribosomal subunit+16S RRNA<br />
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[[1i94]], [[1fka]] - TtRPS19 in 30S ribosomal subunit+16S RRNA<br />
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[[1p87]], [[1p6g]] - EcRPS19 in 30S ribosomal subunit+16S RRNA – Cryo-EM<br />
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[[3bbn]] - RPS19 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach<br />
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=== S19 in small + large ribosomal subunit ===
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[[1ml5]] - EcRPS19 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM<br />
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=== S19 in small ribosomal subunit+ chain release factor ===
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[[3mr8]], [[3ms0]] – TtRPS19 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA <br />
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[[3d5a]], [[3d5c]] - TtRPS19 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[3zvo]] – TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3<br />
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[[2b64]] - TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1<br />
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[[2b9m]] - TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2<br />
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[[2x9r]], [[2x9t]], [[2wh1]], [[2wh3]] - TtRPS19 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA<br />
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[[3f1e]], [[3f1g]] - TtRPS19 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA<br />
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=== S19 in small ribosomal subunit+tRNA+mRNA ===
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[[2hgi]] - TtRPS19 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet<br />
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[[2hgp]] - TtRPS19 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2i2p]], [[2i2u]] - EcRPS19 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2hgr]] - TtRPS19 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA<br />
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[[1yl4]] – TtRPS19 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator<br />
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[[1pns]] – EcRPS19 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA <br />
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[[1xnq]], [[1xnr]] - TtRPS19 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA<br />
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=== S19 in small ribosomal subunit+A-site tRNA ===
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[[2uxd]], [[2uxc]] - TtRPS19 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA<br />
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[[1n32]], [[1n33]] - TtRPS19 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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[[1n34]] - TtRPS19 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA<br />
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[[1xmo]], [[1xmq]] - TtRPS19 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA<br />
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[[2uxb]] - TtRPS19 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA<br />
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=== S19 in small ribosomal subunit+P-site tRNA ===
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[[3i8g]] - TtRPS19 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA<br />
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[[3i8h]], [[3i9b]], [[3i9d]] - TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA<br />
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[[1ibk]] - TtRPS19 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA<br />
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[[2wwl]] - EcRPS19 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - ''Escherichia coli''<br />
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[[3i1q]] - EcRPS19 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA <br />
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[[3i1s]], [[3i1z]], [[3i21]] - EcRPS17 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA<br />
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=== S19 in small ribosomal subunit+A-site tRNA+P-site tRNA ===
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[[1ibl]], [[1ibm]] - TtRPS19 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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=== S19 in small ribosomal subunit+P-site tRNA+E-site tRNA ===
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[[2ow8]] - TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA<br />
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[[2b9o]] - TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA<br />
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[[2qnh]] - TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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=== S19 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA ===
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[[2gy9]], [[2gyb]] - EcRPS19 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM<br />
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[[1jgo]], [[1jgp]], [[1jgq]], [[1gix]] - TtRPS19 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA<br />
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[[3e1a]], [[3e1c]] - EcRPS19 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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=== S19 in small ribosomal subunit + antibiotics ===
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[[1i95]], [[1i97]], [[2hhh]], [[2f4v]] - TtRPS19 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[1hnx]], [[1hnw]], [[1hnz]], [[1fjg]] – TtRPS19 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic<br />
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[[2qbb]], [[2qb9]], [[1vs5]], [[1vs7]] , [[2qan]], [[2qal]], [[2qou]], [[2qow]], [[2qoy]], [[2qp0]], [[2z4k]], [[2z4m]] - EcRPS19 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[2j00]], [[2j02]] - TtRPS19 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA<br />
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[[2wdg]], [[2wdh]], [[2wdk]], [[2wdm]] - TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe+paromomycin<br />
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[[3knj]], [[3knh]] - TtRPS19 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin<br />
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[[3knl]], [[3knn]] - TtRPS19 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin<br />
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=== S19 in small ribosomal subunit + ribosome recycling factor ===
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[[2qbd]], [[2qbf]] – EcRPS19 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor<br />
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[[3r8n]], [[3r8o]] – EcRPS19 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA<br />
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[[2qbh]], [[2qbj]] - EcRPS19 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin<br />
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[[2v46]], [[2v48]] - TtRPS19 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet<br />
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=== S19 in small ribosomal subunit + elongation factor ===
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[[2wri]], [[2wrk]], [[2xsy]], [[2xuy]] - TtRPS19 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G<br />
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[[2wrn]], [[2wrq]] - TtRPS19 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4<br />
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[[3fic]] - TtRPS19 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A<br />
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[[3izv]] – EcRPS19 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU<br />
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[[3izw]] – EcRPS19 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU<br />
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[[2y0u]], [[2y0w]], [[2y0y]], [[2y12]], [[2y10]], [[2y18]], [[2y14]], [[2y16]] – TtRPS19 in 30S ribosomal subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU<br />
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[[2xqd]] – TtRPS19 in 30S ribosomal subunit+THX+E-site tRNA+mRNA +16S RRNA+elongation factor TU-B<br />
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[[3fih]] - EcRPS19 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU<br />
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[[3huw]], [[3huy]] - Ttv in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P<br />
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[[1s1h]] - yRPS19 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast<br />
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=== S19 in small ribosomal subunit + translation initiation factor ===
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[[1i96]] - TtRPS19 in 30S ribosomal subunit+THX+IF3+16S RRNA<br />
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[[1hr0]] - TtRPS19 in 30S ribosomal subunit+THX+IF+16S RRNA<br />
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=== S19 in small ribosomal subunit + various proteins ===
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[[3kiq]], [[3kis]], [[3kiu]], [[3kix]] - TtRPS19 in 30S ribosomal subunit+toxin RelE+16S RRNA<br />
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[[1voq]], [[1vos]], [[1vov]], [[1vox]], [[1voz]] - EcRPS19 in 30S ribosomal subunit+protein Y+16S RRNA<br />
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[[2xfz]], [[2xg1]] - TtRPS19 in 30S ribosomal subunit+tRNA Phe+mRNA+colicin E3+16S RRNA<br />
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[[3a1p]] - TtRPS19+ ribosome maturation factor RIMM<br />
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[[3j00]] – EcRPS19 + 16S RRNA + FTSQ + apolipoprotein A-I<br />
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[[2ykr]] – EcRPS19 + 16S RRNA + GMPPNP + GTPase RSGA<br />
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[[4a2i]] – EcRPS19 + 16S RRNA + GTPase RSGA – Cryo EM
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===S19 in small 40S ribosomal subunit + various proteins===
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[[3iz6]] – RPS19 in 40S ribosomal subunit+RACK1 – wheat – Cryo EM<br />
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== References ==
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[[3o2z]], [[3o30]] – yRPS19 in 40S ribosomal subunit+18S RRNA+RACK1<br />
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<references/>
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[[3jyv]] - RPS19 in 40S ribosomal subunit+tRNA Phe+RACK1+18S RRNA – EM – ''Thermomyces lanuginosus''
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein S19 complex with Cl- ion (PDB code 2v7f)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein S19

Updated on 01-October-2017

2v7f – RPS19 – Pyroccocus abyssi
1qkh, 1qkf - TtRPS19 - Thermus thermophilus – NMR
3a1p – TtRPS19 + ribosome maturation factor

References

  1. ↑ Wool IG, Chan YL, Gluck A. Structure and evolution of mammalian ribosomal proteins. Biochem Cell Biol. 1995 Nov-Dec;73(11-12):933-47. PMID:8722009
  2. ↑ Lv J, Huang XR, Klug J, Frohlich S, Lacher P, Xu A, Meinhardt A, Lan HY. Ribosomal protein S19 is a novel therapeutic agent in inflammatory kidney disease. Clin Sci (Lond). 2013 May;124(10):627-37. doi: 10.1042/CS20120526. PMID:23252627 doi:http://dx.doi.org/10.1042/CS20120526

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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