Talin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:58, 12 December 2023) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]]
+
<StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'>
-
{{STRUCTURE_2x0c| PDB=2x0c | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
[[Talin]] is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, ''i.e.'' the crystal structure of mouse Talin rod ([[2x0c]]).
+
-
 
+
-
{{TOC limit|limit=2}}
+
 +
[[Talin]] is involved in cell-cell contacts. It links integrins to actin<ref>PMID:19416068</ref>. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.
 +
</StructureSection>
== 3D Structures of Talin ==
== 3D Structures of Talin ==
 +
[[Talin 3D structures]]
-
''Updated July 2012''
+
== References ==
-
 
+
<references/>
-
=== Talin subdomains ===
+
</StructureSection>
-
 
+
[[Category: Topic Page]]
-
[[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br />
+
-
[[2kma]] – mTal F0F1 – NMR<br />
+
-
[[2kc1]] - mTal F0 – NMR<br />
+
-
[[2kc2]] - mTal F1 – NMR<br />
+
-
[[2hrj]] - cTal F2 – NMR <br />
+
-
[[1mix]] – cTal F2F3<br />
+
-
[[2kgx]] – mTal F3+mTal fragment – NMR<br />
+
-
[[3ivf]] – mTal FERM domain<br />
+
-
[[2l7n]] – mTal B – NMR<br />
+
-
[[2l10]] – mTal C - NMR
+
-
 
+
-
=== Talin integrin-binding sites ===
+
-
 
+
-
[[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
+
-
[[3g9w]] – mTal F2F3+integrin tail<br />
+
-
[[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br />
+
-
[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
+
-
[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster''
+
-
 
+
-
=== Talin vinculin-binding sites ===
+
-
 
+
-
[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br />
+
-
[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
+
-
[[1u6h]] - cTal VBS2+ vinculin head<br />
+
-
[[1t01]] - cTal VBS1+ vinculin head<br />
+
-
[[1syq]] - hTal VBS1+ vinculin head – human<br />
+
-
[[1rkc]], [[3s90]] - hTal VBS3+ vinculin head<br />
+
-
[[1u89]], [[2l7a]] - mTal VBS2 – NMR<br />
+
-
[[4dj9]] – hTal VBS50 + vinculin head
+
-
 
+
-
=== Talin PIP kinase binding sites ===
+
-
 
+
-
[[1y19]] - mTal F2F3+ PIP kinase C-terminal<br />
+
-
[[2g35]] - mTal F3+PIP kinase peptide – NMR
+
-
 
+
-
=== Layilin binding sites ===
+
-
 
+
-
[[2k00]] - cTal F3+layilin fragment – NMR
+
-
 
+
-
[[Category:Topic Page]]
+

Current revision

Talin rod domain residues 1359-1659 (PDB code 2x0c)

Drag the structure with the mouse to rotate

3D Structures of Talin

Talin 3D structures

References

  1. ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

</StructureSection>

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Talin"
Personal tools