3qm4

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[[Image:3qm4.png|left|200px]]
 
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{{STRUCTURE_3qm4| PDB=3qm4 | SCENE= }}
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==Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex==
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<StructureSection load='3qm4' size='340' side='right'caption='[[3qm4]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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===Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QM4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22308038}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qm4 OCA], [https://pdbe.org/3qm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qm4 RCSB], [https://www.ebi.ac.uk/pdbsum/3qm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qm4 ProSAT]</span></td></tr>
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[[3qm4]] is a 2 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref>
==See Also==
==See Also==
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*[[Cytochrome P450|Cytochrome P450]]
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022308038</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Large Structures]]
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[[Category: Johnson, E F.]]
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[[Category: Johnson EF]]
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[[Category: Stout, C D.]]
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[[Category: Stout CD]]
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[[Category: Wang, A.]]
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[[Category: Wang A]]
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[[Category: Cyp2d6]]
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[[Category: Heme]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: P450]]
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[[Category: P450 2d6]]
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[[Category: Prinomastat]]
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Current revision

Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex

PDB ID 3qm4

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