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4az2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human thrombin - inhibitor complex== | |
| + | <StructureSection load='4az2' size='340' side='right'caption='[[4az2]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4az2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AZ2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9MU:(R)-N-((S)-1-CARBAMIMIDOYL-PIPERIDIN-3-YLMETHYL)-2-(NAPHTHALENE-2-SULFONYLAMINO)-3-PHENYL-PROPIONAMIDE'>9MU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4az2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4az2 OCA], [https://pdbe.org/4az2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4az2 RCSB], [https://www.ebi.ac.uk/pdbsum/4az2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4az2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HIR3P_HIRME HIR3P_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. | ||
| - | + | ==See Also== | |
| - | + | *[[Hirudin 3D structures|Hirudin 3D structures]] | |
| - | + | *[[Thrombin 3D Structures|Thrombin 3D Structures]] | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hirudo medicinalis]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Banner DW]] | ||
| + | [[Category: D'Arcy A]] | ||
| + | [[Category: Hilpert K]] | ||
| + | [[Category: Winkler FK]] | ||
Current revision
Human thrombin - inhibitor complex
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