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4fps
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4fps is ON HOLD until Paper Publication Authors: Immekus, F., Klebe, G. Description: tRNA-Guanine Transglycosylase in complex with adamantyl-substi...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==tRNA-Guanine Transglycosylase in complex with adamantyl-substituted lin-benzoguanine ligand== | |
| + | <StructureSection load='4fps' size='340' side='right'caption='[[4fps]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fps]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FPS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0UX:6-AMINO-2-(METHYLAMINO)-4-(2-{[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YLMETHYL]AMINO}ETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0UX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fps OCA], [https://pdbe.org/4fps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fps RCSB], [https://www.ebi.ac.uk/pdbsum/4fps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fps ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | ||
| - | + | ==See Also== | |
| - | + | *[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]] | ||
| + | [[Category: Immekus F]] | ||
| + | [[Category: Klebe G]] | ||
Current revision
tRNA-Guanine Transglycosylase in complex with adamantyl-substituted lin-benzoguanine ligand
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