4fqo

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(New page: '''Unreleased structure''' The entry 4fqo is ON HOLD Authors: McKnight, L.E., Raman, E.P., Bezawada, P., Kudrimoti, S., Wilder, P.T., Hartman, K.G., Toth, E.A., Coop, A., MacKerrell, A....)
Current revision (11:23, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4fqo is ON HOLD
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==Crystal Structure of Calcium-Loaded S100B Bound to SBi4211==
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<StructureSection load='4fqo' size='340' side='right'caption='[[4fqo]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZ3:4,4-[HEPTANE-1,7-DIYLBIS(OXY)]DIBENZENECARBOXIMIDAMIDE'>AZ3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqo OCA], [https://pdbe.org/4fqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqo RCSB], [https://www.ebi.ac.uk/pdbsum/4fqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
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Authors: McKnight, L.E., Raman, E.P., Bezawada, P., Kudrimoti, S., Wilder, P.T., Hartman, K.G., Toth, E.A., Coop, A., MacKerrell, A.D., Weber, D.J.
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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Description: Crystal Structure of Calcium-Loaded S100B Bound to SBi4211
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Large Structures]]
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[[Category: Bezawada P]]
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[[Category: Coop A]]
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[[Category: Hartman KG]]
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[[Category: Kudrimoti S]]
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[[Category: MacKerrell AD]]
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[[Category: McKnight LE]]
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[[Category: Raman EP]]
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[[Category: Toth EA]]
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[[Category: Weber DJ]]
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[[Category: Wilder PT]]

Current revision

Crystal Structure of Calcium-Loaded S100B Bound to SBi4211

PDB ID 4fqo

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