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4frw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human nectin-4 extracellular fragment D1-D2== | |
| + | <StructureSection load='4frw' size='340' side='right'caption='[[4frw]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4frw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FRW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4frw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frw OCA], [https://pdbe.org/4frw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4frw RCSB], [https://www.ebi.ac.uk/pdbsum/4frw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4frw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NECT4_HUMAN NECT4_HUMAN] Ectodermal dysplasia-syndactyly syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NECT4_HUMAN NECT4_HUMAN] Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus.<ref>PMID:22048310</ref> <ref>PMID:23202587</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brasch J]] | ||
| + | [[Category: Harrison OJ]] | ||
| + | [[Category: Jin X]] | ||
| + | [[Category: Shapiro L]] | ||
Current revision
Crystal structure of human nectin-4 extracellular fragment D1-D2
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