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4fs0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4fs0 is ON HOLD Authors: Harrison, O.J., Brasch, J., Shapiro, L. Description: Crystal structure of mutant F136D of mouse nectin-2 extracellular fra...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mutant F136D of mouse nectin-2 extracellular fragment D1-D2== | |
| + | <StructureSection load='4fs0' size='340' side='right'caption='[[4fs0]], [[Resolution|resolution]] 3.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fs0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FS0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fs0 OCA], [https://pdbe.org/4fs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fs0 RCSB], [https://www.ebi.ac.uk/pdbsum/4fs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fs0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NECT2_MOUSE NECT2_MOUSE] Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.[UniProtKB:Q92692] | ||
| - | + | ==See Also== | |
| - | + | *[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Brasch J]] | ||
| + | [[Category: Harrison OJ]] | ||
| + | [[Category: Shapiro L]] | ||
Current revision
Crystal structure of mutant F136D of mouse nectin-2 extracellular fragment D1-D2
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