4erp
From Proteopedia
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| - | [[Image:4erp.jpg|left|200px]] | ||
| - | + | ==Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex== | |
| + | <StructureSection load='4erp' size='340' side='right'caption='[[4erp]], [[Resolution|resolution]] 4.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4erp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ERP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ERP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.45Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4erp OCA], [https://pdbe.org/4erp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4erp RCSB], [https://www.ebi.ac.uk/pdbsum/4erp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4erp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines. | ||
| - | == | + | ==See Also== |
| - | + | *[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: Escherichia coli | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Drennan CL]] |
| - | [[Category: Drennan | + | [[Category: Zimanyi CM]] |
| - | [[Category: Zimanyi | + | |
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Current revision
Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex
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