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4ew0

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[[Image:4ew0.jpg|left|200px]]
 
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{{STRUCTURE_4ew0| PDB=4ew0 | SCENE= }}
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==mouse MBD4 glycosylase domain in complex with a G:5hmU (5-hydroxymethyluracil) mismatch==
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<StructureSection load='4ew0' size='340' side='right'caption='[[4ew0]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ew0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EW0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5HU:5-HYDROXYMETHYLURIDINE-2-DEOXY-5-MONOPHOSPHATE'>5HU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ew0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ew0 OCA], [https://pdbe.org/4ew0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ew0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ew0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ew0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBD4_MOUSE MBD4_MOUSE] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
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===mouse MBD4 glycosylase domain in complex with a G:5hmU (5-hydroxymethyluracil) mismatch===
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==See Also==
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*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
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{{ABSTRACT_PUBMED_22740654}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4ew0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EW0 OCA].
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==Reference==
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<ref group="xtra">PMID:022740654</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cheng, X.]]
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[[Category: Cheng X]]
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[[Category: Hashimoto, H.]]
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[[Category: Hashimoto H]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: 5-hydroxymethyluracil]]
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[[Category: 5-methylcytosine]]
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[[Category: Active dna demethylation]]
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[[Category: Deamination]]
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[[Category: Dna glycosylase]]
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[[Category: Helix-hairpin-helix]]
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[[Category: Hydrolase-dna complex]]
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Current revision

mouse MBD4 glycosylase domain in complex with a G:5hmU (5-hydroxymethyluracil) mismatch

PDB ID 4ew0

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