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3uzt

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[[Image:3uzt.jpg|left|200px]]
 
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{{STRUCTURE_3uzt| PDB=3uzt | SCENE= }}
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==Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2==
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<StructureSection load='3uzt' size='340' side='right'caption='[[3uzt]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3uzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UZT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uzt OCA], [https://pdbe.org/3uzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uzt RCSB], [https://www.ebi.ac.uk/pdbsum/3uzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uzt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity).
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===Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2===
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==See Also==
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*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]
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{{ABSTRACT_PUBMED_22727813}}
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*[[Beta-adrenergic receptor kinase|Beta-adrenergic receptor kinase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3uzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZT OCA].
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==Reference==
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<ref group="xtra">PMID:022727813</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Large Structures]]
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[[Category: Tesmer, V M.]]
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[[Category: Tesmer JJG]]
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[[Category: G protein-coupled receptor phosphorylation]]
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[[Category: Tesmer VM]]
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[[Category: Pleckstrin homology domain]]
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[[Category: Protein kinase fold]]
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[[Category: Protein-rna complex]]
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[[Category: Rgs homology domain]]
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[[Category: Rna aptamer]]
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[[Category: Transferase-rna complex]]
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Current revision

Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2

PDB ID 3uzt

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