3tik

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[[Image:3tik.jpg|left|200px]]
 
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{{STRUCTURE_3tik| PDB=3tik | SCENE= }}
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==Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one==
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<StructureSection load='3tik' size='340' side='right'caption='[[3tik]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TIK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JKF:6-[(R)-(4-CHLOROPHENYL)(METHOXY)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(2,6-DIFLUOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE'>JKF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tik OCA], [https://pdbe.org/3tik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tik RCSB], [https://www.ebi.ac.uk/pdbsum/3tik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tik ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q385E8_TRYB2 Q385E8_TRYB2]
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===Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3tik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIK OCA].
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[[Category: Large Structures]]
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[[Category: Sterol 14-demethylase]]
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[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Buckner, F S.]]
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[[Category: Buckner FS]]
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[[Category: Gelb, M H.]]
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[[Category: Gelb MH]]
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[[Category: Hargrove, T Y.]]
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[[Category: Hargrove TY]]
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[[Category: Kraus, J M.]]
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[[Category: Kraus JM]]
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[[Category: Lepesheva, G I.]]
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[[Category: Lepesheva GI]]
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[[Category: Waterman, M R.]]
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[[Category: Waterman MR]]
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[[Category: Wawrzak, Z.]]
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[[Category: Wawrzak Z]]
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[[Category: Cyp51]]
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[[Category: Cytochrome p450 fold]]
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[[Category: Cytochrome p450 reductase]]
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[[Category: Endoplasmic reticulum membrane]]
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[[Category: Heme]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Sterol 14-alpha demethylase]]
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[[Category: Sterol biosynthesis]]
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Current revision

Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one

PDB ID 3tik

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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