4f7h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:18, 14 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4f7h.png|left|200px]]
 
-
{{STRUCTURE_4f7h| PDB=4f7h | SCENE= }}
+
==The crystal structure of kindlin-2 pleckstrin homology domain in free form==
-
 
+
<StructureSection load='4f7h' size='340' side='right'caption='[[4f7h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
===The crystal structure of kindlin-2 pleckstrin homology domain in free form===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4f7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F7H FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_22653426}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f7h OCA], [https://pdbe.org/4f7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f7h RCSB], [https://www.ebi.ac.uk/pdbsum/4f7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f7h ProSAT]</span></td></tr>
-
[[4f7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7H OCA].
+
</table>
-
 
+
== Function ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/FERM2_HUMAN FERM2_HUMAN] Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.<ref>PMID:12679033</ref> <ref>PMID:18458155</ref> <ref>PMID:21325030</ref> <ref>PMID:22699938</ref> <ref>PMID:22030399</ref> <ref>PMID:22078565</ref>
-
<ref group="xtra">PMID:022653426</ref><references group="xtra"/>
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Liu, Y.]]
+
[[Category: Large Structures]]
-
[[Category: Qin, J.]]
+
[[Category: Liu Y]]
-
[[Category: Ye, S.]]
+
[[Category: Qin J]]
-
[[Category: Zhang, R.]]
+
[[Category: Ye S]]
-
[[Category: Zhu, Y.]]
+
[[Category: Zhang R]]
-
[[Category: Beta-barrel]]
+
[[Category: Zhu Y]]
-
[[Category: Cell adhesion]]
+
-
[[Category: Cytoplasmic membrane]]
+
-
[[Category: Integrin activation]]
+
-
[[Category: Membrane binding]]
+

Current revision

The crystal structure of kindlin-2 pleckstrin homology domain in free form

PDB ID 4f7h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4f7h"
Personal tools