3uom

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[[Image:3uom.png|left|200px]]
 
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{{STRUCTURE_3uom| PDB=3uom | SCENE= }}
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==Ca2+ complex of Human skeletal calsequestrin==
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<StructureSection load='3uom' size='340' side='right'caption='[[3uom]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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===Ca2+ complex of Human skeletal calsequestrin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3uom]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UOM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22337878}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uom OCA], [https://pdbe.org/3uom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uom RCSB], [https://www.ebi.ac.uk/pdbsum/3uom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uom ProSAT]</span></td></tr>
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[[3uom]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOM OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CASQ1_HUMAN CASQ1_HUMAN] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.<ref>PMID:22337878</ref> <ref>PMID:22337878</ref>
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<ref group="xtra">PMID:022337878</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Danna, B R.]]
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[[Category: Large Structures]]
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[[Category: Kang, C H.]]
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[[Category: Danna BR]]
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[[Category: Lewis, K M.]]
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[[Category: Kang CH]]
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[[Category: Nissen, M S.]]
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[[Category: Lewis KM]]
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[[Category: Sanchez, E J.]]
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[[Category: Nissen MS]]
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[[Category: Calcium binding]]
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[[Category: Sanchez EJ]]
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[[Category: Calcium-binding protein]]
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[[Category: Sarcoplasmic reticulum]]
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[[Category: Thioredoxin-like fold]]
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Current revision

Ca2+ complex of Human skeletal calsequestrin

PDB ID 3uom

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