3un0

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[[Image:3un0.png|left|200px]]
 
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{{STRUCTURE_3un0| PDB=3un0 | SCENE= }}
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==Crystal Structure of MDC1 FHA Domain==
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<StructureSection load='3un0' size='340' side='right'caption='[[3un0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal Structure of MDC1 FHA Domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3un0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UN0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22234878}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3un0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3un0 OCA], [https://pdbe.org/3un0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3un0 RCSB], [https://www.ebi.ac.uk/pdbsum/3un0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3un0 ProSAT]</span></td></tr>
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[[3un0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UN0 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/MDC1_HUMAN MDC1_HUMAN] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.<ref>PMID:14695167</ref> <ref>PMID:12475977</ref> <ref>PMID:12499369</ref> <ref>PMID:12551934</ref> <ref>PMID:12611903</ref> <ref>PMID:12607003</ref> <ref>PMID:12607004</ref> <ref>PMID:12607005</ref> <ref>PMID:15201865</ref> <ref>PMID:15377652</ref>
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<ref group="xtra">PMID:022234878</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Clapperton, J A.]]
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[[Category: Large Structures]]
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[[Category: Haire, L F.]]
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[[Category: Clapperton JA]]
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[[Category: Li, J.]]
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[[Category: Haire LF]]
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[[Category: Lloyd, J.]]
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[[Category: Li J]]
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[[Category: Smerdon, S J.]]
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[[Category: Lloyd J]]
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[[Category: Cell cycle]]
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[[Category: Smerdon SJ]]
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[[Category: Dna-damage]]
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[[Category: Fha domain]]
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Current revision

Crystal Structure of MDC1 FHA Domain

PDB ID 3un0

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OCA

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