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4b1r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Tetracycline repressor class D mutant H100A in complex with iso-7- Chlortetracycline== | |
| + | <StructureSection load='4b1r' size='340' side='right'caption='[[4b1r]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4b1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B1R FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ITC:ISO-7-CHLORTETRACYCLINE'>ITC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1r OCA], [https://pdbe.org/4b1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b1r RCSB], [https://www.ebi.ac.uk/pdbsum/4b1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. | ||
| - | + | ==See Also== | |
| - | + | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Eltschkner S]] | ||
| + | [[Category: Hinrichs W]] | ||
| + | [[Category: Palm GJ]] | ||
| + | [[Category: Schneider J]] | ||
Current revision
Tetracycline repressor class D mutant H100A in complex with iso-7- Chlortetracycline
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