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4fzh
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4fzh is ON HOLD Authors: Yuan, P., Paterson, R.G., Leser, G.P., Lamb, R.A., Jardetzky, T.S. Description: Structure of the Ulster Strain Newcastle D...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Ulster Strain Newcastle Disease Virus Hemagglutinin-Neuraminidase Reveals Auto-Inhibitory Interactions Associated with Low Virulence== | |
| + | <StructureSection load='4fzh' size='340' side='right'caption='[[4fzh]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fzh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Newcastle_disease_virus_Ulster/67 Newcastle disease virus Ulster/67]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5008Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzh OCA], [https://pdbe.org/4fzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fzh RCSB], [https://www.ebi.ac.uk/pdbsum/4fzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HN_NDVU HN_NDVU] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Newcastle disease virus Ulster/67]] | ||
| + | [[Category: Jardetzky TS]] | ||
| + | [[Category: Lamb RA]] | ||
| + | [[Category: Leser GP]] | ||
| + | [[Category: Paterson RG]] | ||
| + | [[Category: Yuan P]] | ||
Current revision
Structure of the Ulster Strain Newcastle Disease Virus Hemagglutinin-Neuraminidase Reveals Auto-Inhibitory Interactions Associated with Low Virulence
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