4g1z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor== | |
| - | + | <StructureSection load='4g1z' size='340' side='right'caption='[[4g1z]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4g1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VP:3-(5-{[3,4-BIS(HYDROXYMETHYL)BENZYL]OXY}-2-ETHYL-2-PROPYLBIPHENYL-4-YL)PENTAN-3-OL'>0VP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1z OCA], [https://pdbe.org/4g1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1z RCSB], [https://www.ebi.ac.uk/pdbsum/4g1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Danio rerio]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ciesielski F]] | ||
| + | [[Category: Moras D]] | ||
| + | [[Category: Rochel N]] | ||
| + | [[Category: Sato Y]] | ||
Current revision
Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor
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