4g21
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4g21 is ON HOLD Authors: Ciesielski, F., Sato, Y., Moras, D., Rochel, N. Description: Structural basis for the accommodation of bis-and tris-aromat...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor== | |
| - | + | <StructureSection load='4g21' size='340' side='right'caption='[[4g21]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4g21]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G21 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VP:3-(5-{[3,4-BIS(HYDROXYMETHYL)BENZYL]OXY}-2-ETHYL-2-PROPYLBIPHENYL-4-YL)PENTAN-3-OL'>0VP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g21 OCA], [https://pdbe.org/4g21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g21 RCSB], [https://www.ebi.ac.uk/pdbsum/4g21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g21 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Danio rerio]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ciesielski F]] | ||
| + | [[Category: Moras D]] | ||
| + | [[Category: Rochel N]] | ||
| + | [[Category: Sato Y]] | ||
Current revision
Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor
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