4ee0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:03, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4ee0.jpg|left|200px]]
 
-
{{STRUCTURE_4ee0| PDB=4ee0 | SCENE= }}
+
==Crystal structure of hH-PGDS with water displacing inhibitor==
 +
<StructureSection load='4ee0' size='340' side='right'caption='[[4ee0]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4ee0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EE0 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0O4:4-(ISOQUINOLIN-1-YL)-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>0O4</scene>, <scene name='pdbligand=GSF:L-GAMMA-GLUTAMYL-3-SULFINO-L-ALANYLGLYCINE'>GSF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ee0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ee0 OCA], [https://pdbe.org/4ee0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ee0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ee0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ee0 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
-
===Crystal structure of hH-PGDS with water displacing inhibitor===
+
==See Also==
-
 
+
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
-
{{ABSTRACT_PUBMED_22546671}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[4ee0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EE0 OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022546671</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Day, J E.]]
+
[[Category: Large Structures]]
-
[[Category: Thorarensen, A.]]
+
[[Category: Day JE]]
-
[[Category: Trujillo, J I.]]
+
[[Category: Thorarensen A]]
-
[[Category: Inhibitor]]
+
[[Category: Trujillo JI]]
-
[[Category: Isomerase-isomerase inhibitor complex]]
+
-
[[Category: Solvent replacement]]
+

Current revision

Crystal structure of hH-PGDS with water displacing inhibitor

PDB ID 4ee0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ee0"
Personal tools