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3um8

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[[Image:3um8.jpg|left|200px]]
 
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{{STRUCTURE_3um8| PDB=3um8 | SCENE= }}
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==Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH==
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<StructureSection load='3um8' size='340' side='right'caption='[[3um8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3um8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UM8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3um8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3um8 OCA], [https://pdbe.org/3um8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3um8 RCSB], [https://www.ebi.ac.uk/pdbsum/3um8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3um8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A7UD81_PLAFA A7UD81_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]
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===Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH===
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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{{ABSTRACT_PUBMED_22526319}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3um8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UM8 OCA].
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==Reference==
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<ref group="xtra">PMID:022526319</ref><references group="xtra"/>
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Chitnumsub, P.]]
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[[Category: Chitnumsub P]]
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[[Category: Kamchonwongpaisan, S.]]
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[[Category: Kamchonwongpaisan S]]
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[[Category: Vanichtanankul, J.]]
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[[Category: Vanichtanankul J]]
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[[Category: Yuthavong, Y.]]
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[[Category: Yuthavong Y]]
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[[Category: Antifolate]]
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[[Category: Cycloguanil]]
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[[Category: Malarial dhfr-t]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH

PDB ID 3um8

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