3um8
From Proteopedia
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| - | [[Image:3um8.jpg|left|200px]] | ||
| - | + | ==Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH== | |
| + | <StructureSection load='3um8' size='340' side='right'caption='[[3um8]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3um8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UM8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3um8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3um8 OCA], [https://pdbe.org/3um8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3um8 RCSB], [https://www.ebi.ac.uk/pdbsum/3um8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3um8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A7UD81_PLAFA A7UD81_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389] | ||
| - | == | + | ==See Also== |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
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[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
| - | [[Category: Chitnumsub | + | [[Category: Chitnumsub P]] |
| - | [[Category: Kamchonwongpaisan | + | [[Category: Kamchonwongpaisan S]] |
| - | [[Category: Vanichtanankul | + | [[Category: Vanichtanankul J]] |
| - | [[Category: Yuthavong | + | [[Category: Yuthavong Y]] |
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Current revision
Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH
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