3vd1
From Proteopedia
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| - | [[Image:3vd1.png|left|200px]] | ||
| - | + | ==structure of p73 DNA binding domain tetramer modulates p73 transactivation== | |
| + | <StructureSection load='3vd1' size='340' side='right'caption='[[3vd1]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3vd1]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VD1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vd1 OCA], [https://pdbe.org/3vd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vd1 RCSB], [https://www.ebi.ac.uk/pdbsum/3vd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vd1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[P73|P73]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [[ | + | </StructureSection> |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Ethayathulla AS]] |
| - | [[Category: | + | [[Category: Nguyen S]] |
| - | [[Category: | + | [[Category: Tse PW]] |
| - | [[Category: | + | [[Category: Viadiu H]] |
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Current revision
structure of p73 DNA binding domain tetramer modulates p73 transactivation
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