2l4k

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[[Image:2l4k.png|left|200px]]
 
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{{STRUCTURE_2l4k| PDB=2l4k | SCENE= }}
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==Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139==
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<StructureSection load='2l4k' size='340' side='right'caption='[[2l4k]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l4k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4k OCA], [https://pdbe.org/2l4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4k RCSB], [https://www.ebi.ac.uk/pdbsum/2l4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRB7_HUMAN GRB7_HUMAN] Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).<ref>PMID:10893408</ref> <ref>PMID:12021278</ref> <ref>PMID:12223469</ref> <ref>PMID:20622016</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report a refinement in implicit water of the previously published solution structure of the Grb7-SH2 domain bound to the erbB2 receptor peptide pY1139. Structure quality measures indicate substantial improvement, with residues in the most favored regions of the Ramachandran plot increasing by 14 % and with WHAT IF statistics (Vriend, G. J Mol Graph, 1990, 8(1), 52-56) falling closer to expected values for well-refined structures.
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===Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139===
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Water Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139.,Pias SC, Johnson DL, Smith DE, Lyons BA Protein Pept Lett. 2012 Apr 5. PMID:22702899<ref>PMID:22702899</ref>
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{{ABSTRACT_PUBMED_22702899}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l4k" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2l4k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4K OCA].
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*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022702899</ref><ref group="xtra">PMID:012975581</ref><ref group="xtra">PMID:012061724</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Brescia, P J.]]
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[[Category: Brescia PJ]]
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[[Category: Daly, R J.]]
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[[Category: Daly RJ]]
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[[Category: Ivancic, M.]]
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[[Category: Ivancic M]]
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[[Category: Johnson, D L.]]
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[[Category: Johnson DL]]
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[[Category: Lyons, B A.]]
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[[Category: Lyons BA]]
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[[Category: Pias, S C.]]
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[[Category: Pias SC]]
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[[Category: Smith, D E.]]
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[[Category: Smith DE]]
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[[Category: Erbb2 receptor]]
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[[Category: Grb7]]
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[[Category: Sh2 domain]]
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[[Category: Signaling protein]]
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[[Category: Water refinement]]
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Current revision

Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139

PDB ID 2l4k

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