1a8d
From Proteopedia
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| - | [[Image:1a8d.gif|left|200px]]<br /><applet load="1a8d" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1a8d, resolution 1.57Å" /> | ||
| - | '''TETANUS TOXIN C FRAGMENT'''<br /> | ||
| - | == | + | ==TETANUS TOXIN C FRAGMENT== |
| - | + | <StructureSection load='1a8d' size='340' side='right'caption='[[1a8d]], [[Resolution|resolution]] 1.57Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1a8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8D FirstGlance]. <br> | |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8d OCA], [https://pdbe.org/1a8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8d RCSB], [https://www.ebi.ac.uk/pdbsum/1a8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8d ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |
| - | + | == Evolutionary Conservation == | |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8d_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8d ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Tetanus toxin|Tetanus toxin]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Clostridium tetani]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Knapp M]] | ||
| + | [[Category: Rupp B]] | ||
Current revision
TETANUS TOXIN C FRAGMENT
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