3twl

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[[Image:3twl.jpg|left|200px]]
 
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{{STRUCTURE_3twl| PDB=3twl | SCENE= }}
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==Crystal structure of Arabidopsis thaliana FPG==
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<StructureSection load='3twl' size='340' side='right'caption='[[3twl]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3twl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twl OCA], [https://pdbe.org/3twl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twl RCSB], [https://www.ebi.ac.uk/pdbsum/3twl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FPG_ARATH FPG_ARATH] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Can process efficiently 4,6-diamino-5-formamidopyrimidine (FapyA), 2,6-diamino-4- hydroxy-5-formamidopyrimidine (FapyG) and the further oxidation products of 8-oxoguanine (8-oxoG), such as guanidinohydantoin and spiroiminodihydantoin. Has marginal activity towards 8-oxoG. Has AP (apurinic/apyrimidinic) lyase activity. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.<ref>PMID:11272725</ref> <ref>PMID:22789755</ref> <ref>PMID:9819050</ref>
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===Crystal structure of Arabidopsis thaliana FPG===
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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{{ABSTRACT_PUBMED_22789755}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3twl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWL OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:022789755</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: DNA-formamidopyrimidine glycosylase]]
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[[Category: Large Structures]]
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[[Category: Aller, P.]]
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[[Category: Aller P]]
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[[Category: Doublie, S.]]
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[[Category: Doublie S]]
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[[Category: Duclos, S.]]
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[[Category: Duclos S]]
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[[Category: Wallace, S S.]]
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[[Category: Wallace SS]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Dna-binding]]
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[[Category: Glycosidase]]
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[[Category: Helix two turns helix]]
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[[Category: Hydrolase]]
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[[Category: Lyase]]
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[[Category: Multifunctional enzyme]]
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[[Category: Zinc-less finger]]
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Current revision

Crystal structure of Arabidopsis thaliana FPG

PDB ID 3twl

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