4g0m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:24, 1 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4g0m.jpg|left|200px]]
 
-
{{STRUCTURE_4g0m| PDB=4g0m | SCENE= }}
+
==Crystal structure of Arabidopsis thaliana AGO2 MID domain==
 +
<StructureSection load='4g0m' size='340' side='right'caption='[[4g0m]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4g0m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0M FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.306&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0m OCA], [https://pdbe.org/4g0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0m RCSB], [https://www.ebi.ac.uk/pdbsum/4g0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0m ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AGO2_ARATH AGO2_ARATH] Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates mainly with siRNAs of 21 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine. Probably involved in antiviral RNA silencing. Associates with siRNA derived from cucumber mosaic virus (CMV). Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO2 function in RNA silencing. Required to direct NERD-dependent DNA methylation and silencing.<ref>PMID:17869110</ref> <ref>PMID:18342361</ref> <ref>PMID:18342362</ref> <ref>PMID:18344228</ref> <ref>PMID:22940247</ref>
-
===Crystal structure of Arabidopsis thaliana AGO2 MID domain===
+
==See Also==
-
 
+
*[[Argonaute 3D structures|Argonaute 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[4g0m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0M OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
-
[[Category: Frank, F.]]
+
[[Category: Large Structures]]
-
[[Category: Hauver, J.]]
+
[[Category: Frank F]]
-
[[Category: Nagar, B.]]
+
[[Category: Hauver J]]
-
[[Category: Sonenberg, N.]]
+
[[Category: Nagar B]]
-
[[Category: Gene regulation]]
+
[[Category: Sonenberg N]]
-
[[Category: Mid domain]]
+
-
[[Category: Small rna 5' nucleotide recognition]]
+

Current revision

Crystal structure of Arabidopsis thaliana AGO2 MID domain

PDB ID 4g0m

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4g0m"
Personal tools