4g0o

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[[Image:4g0o.jpg|left|200px]]
 
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{{STRUCTURE_4g0o| PDB=4g0o | SCENE= }}
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==Crystal structure of Arabidopsis thaliana AGO5 MID domain==
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<StructureSection load='4g0o' size='340' side='right'caption='[[4g0o]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g0o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.186&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0o OCA], [https://pdbe.org/4g0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0o RCSB], [https://www.ebi.ac.uk/pdbsum/4g0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AGO5_ARATH AGO5_ARATH] Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates with siRNAs of various sizes, from 21-24 nucleotide in length and preferentially recruits small RNAs with a 5' terminal cytosine. Probably involved in antiviral RNA silencing. Associates with siRNAs derived from cucumber mosaic virus (CMV). Targeted by the turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO5 function in RNA silencing.<ref>PMID:17869110</ref> <ref>PMID:18342361</ref> <ref>PMID:18344228</ref>
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===Crystal structure of Arabidopsis thaliana AGO5 MID domain===
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==See Also==
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*[[Argonaute 3D structures|Argonaute 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4g0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0O OCA].
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Frank, F.]]
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[[Category: Large Structures]]
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[[Category: Hauver, J.]]
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[[Category: Frank F]]
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[[Category: Nagar, B.]]
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[[Category: Hauver J]]
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[[Category: Sonenberg, N.]]
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[[Category: Nagar B]]
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[[Category: Gene regulation]]
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[[Category: Sonenberg N]]
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[[Category: Mid domain]]
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[[Category: Small rna 5' nucleotide recognition]]
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Current revision

Crystal structure of Arabidopsis thaliana AGO5 MID domain

PDB ID 4g0o

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