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1l3x
From Proteopedia
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| - | [[Image:1l3x.png|left|200px]] | ||
| - | + | ==Solution Structure of Novel Disintegrin Salmosin== | |
| - | + | <StructureSection load='1l3x' size='340' side='right'caption='[[1l3x]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1l3x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_brevicaudus Gloydius brevicaudus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1iq2 1iq2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L3X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l3x OCA], [https://pdbe.org/1l3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l3x RCSB], [https://www.ebi.ac.uk/pdbsum/1l3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l3x ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1l3x]] is a 1 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/VM2HS_GLOBR VM2HS_GLOBR] Metalloproteinase hxl-1: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).<ref>PMID:9722022</ref> <ref>PMID:9856345</ref> <ref>PMID:10446992</ref> <ref>PMID:10944460</ref> <ref>PMID:14977354</ref> Disintegrin salmosin-1: inhibits GPIIb/GPIIIa (ITGA2B/ITGB3) binding to immobilized fibrinogen with an IC(50) of 2.2 nM and ADP-induced platelet aggregation with an IC(50) of 131 nM, respectively. Inhibits angiogenesis.<ref>PMID:9722022</ref> <ref>PMID:9856345</ref> <ref>PMID:10446992</ref> <ref>PMID:10944460</ref> <ref>PMID:14977354</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/1l3x_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l3x ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Disintegrin|Disintegrin]] | *[[Disintegrin|Disintegrin]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Gloydius brevicaudus]] | [[Category: Gloydius brevicaudus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Lee W]] |
| - | [[Category: | + | [[Category: Shin J]] |
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| - | + | ||
Current revision
Solution Structure of Novel Disintegrin Salmosin
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