1aft
From Proteopedia
(Difference between revisions)
| (14 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1aft.gif|left|200px]]<br /><applet load="1aft" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1aft" /> | ||
| - | '''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES'''<br /> | ||
| - | == | + | ==SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES== |
| + | <StructureSection load='1aft' size='340' side='right'caption='[[1aft]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1aft]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AFT FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 26 models</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aft OCA], [https://pdbe.org/1aft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aft RCSB], [https://www.ebi.ac.uk/pdbsum/1aft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aft ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RIR2_MOUSE RIR2_MOUSE] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors. | The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors. | ||
| - | + | NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.,Fisher A, Laub PB, Cooperman BS Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667<ref>PMID:7583667</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1aft" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| - | [[Category: Barwis | + | <references/> |
| - | [[Category: Cooperman | + | __TOC__ |
| - | [[Category: Fisher | + | </StructureSection> |
| - | [[Category: Furst | + | [[Category: Large Structures]] |
| - | [[Category: Hamann | + | [[Category: Barwis BA]] |
| - | [[Category: Laub | + | [[Category: Cooperman BS]] |
| - | + | [[Category: Fisher AL]] | |
| - | + | [[Category: Furst GT]] | |
| - | + | [[Category: Hamann CS]] | |
| - | + | [[Category: Laub PB]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES
| |||||||||||
Categories: Large Structures | Barwis BA | Cooperman BS | Fisher AL | Furst GT | Hamann CS | Laub PB
