3lqs

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[[Image:3lqs.png|left|200px]]
 
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{{STRUCTURE_3lqs| PDB=3lqs | SCENE= }}
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==Complex Structure of D-Amino Acid Aminotransferase and 4-amino-4,5-dihydro-thiophenecarboxylic acid (ADTA)==
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<StructureSection load='3lqs' size='340' side='right'caption='[[3lqs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Complex Structure of D-Amino Acid Aminotransferase and 4-amino-4,5-dihydro-thiophenecarboxylic acid (ADTA)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp._YM-1 Bacillus sp. YM-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LQS FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20192272}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PSZ:4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC+ACID'>PSZ</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lqs OCA], [https://pdbe.org/3lqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lqs RCSB], [https://www.ebi.ac.uk/pdbsum/3lqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lqs ProSAT]</span></td></tr>
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[[3lqs]] is a 2 chain structure of [[Aspartate Aminotransferase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_sp. Bacillus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQS OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DAAA_BACYM DAAA_BACYM] Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second-half reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components.<ref>PMID:2914916</ref> <ref>PMID:9538014</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/3lqs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lqs ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aspartate Aminotransferase|Aspartate Aminotransferase]]
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*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020192272</ref><references group="xtra"/>
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__TOC__
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[[Category: Bacillus sp.]]
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</StructureSection>
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[[Category: D-amino-acid transaminase]]
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[[Category: Bacillus sp. YM-1]]
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[[Category: Fu, M.]]
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[[Category: Large Structures]]
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[[Category: Lepore, B W.]]
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[[Category: Fu M]]
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[[Category: Liu, D.]]
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[[Category: Lepore BW]]
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[[Category: Manning, J M.]]
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[[Category: Liu D]]
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[[Category: Peng, Y.]]
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[[Category: Manning JM]]
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[[Category: Ringe, D.]]
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[[Category: Peng Y]]
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[[Category: Silverman, R B.]]
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[[Category: Ringe D]]
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[[Category: Yasuda, C.]]
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[[Category: Silverman RB]]
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[[Category: Aminotransferase]]
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[[Category: Yasuda C]]
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[[Category: Mechanism-based inhibitor]]
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[[Category: Plp aminotransferase]]
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[[Category: Pyridoxal phosphate]]
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[[Category: R-adta]]
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[[Category: Stereo-specificity]]
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[[Category: Transferase]]
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Current revision

Complex Structure of D-Amino Acid Aminotransferase and 4-amino-4,5-dihydro-thiophenecarboxylic acid (ADTA)

PDB ID 3lqs

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