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1bf9

From Proteopedia

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[[Image:1bf9.png|left|200px]]
 
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{{STRUCTURE_1bf9| PDB=1bf9 | SCENE= }}
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==N-TERMINAL EGF-LIKE DOMAIN FROM HUMAN FACTOR VII, NMR, 23 STRUCTURES==
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<StructureSection load='1bf9' size='340' side='right'caption='[[1bf9]]' scene=''>
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===N-TERMINAL EGF-LIKE DOMAIN FROM HUMAN FACTOR VII, NMR, 23 STRUCTURES===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bf9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BF9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9692950}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bf9 OCA], [https://pdbe.org/1bf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bf9 RCSB], [https://www.ebi.ac.uk/pdbsum/1bf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bf9 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1bf9]] is a 1 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF9 OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/1bf9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bf9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Factor VIIa|Factor VIIa]]
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*[[Factor VIIa 3D structures|Factor VIIa 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009692950</ref><references group="xtra"/>
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__TOC__
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[[Category: Coagulation factor VIIa]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Drakenberg, T.]]
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[[Category: Large Structures]]
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[[Category: Finn, B E.]]
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[[Category: Drakenberg T]]
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[[Category: Forsen, S.]]
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[[Category: Finn BE]]
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[[Category: Gippert, G P.]]
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[[Category: Forsen S]]
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[[Category: Muranyi, A.]]
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[[Category: Gippert GP]]
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[[Category: Stenflo, J.]]
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[[Category: Muranyi A]]
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[[Category: Blood coagulation]]
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[[Category: Stenflo J]]
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[[Category: Egf]]
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[[Category: Hydrolase]]
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[[Category: Serine protease]]
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Current revision

N-TERMINAL EGF-LIKE DOMAIN FROM HUMAN FACTOR VII, NMR, 23 STRUCTURES

PDB ID 1bf9

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