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2cyc

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[[Image:2cyc.png|left|200px]]
 
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{{STRUCTURE_2cyc| PDB=2cyc | SCENE= }}
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==Crystal structure of Tyrosyl-tRNA Synthetase complexed with L-tyrosine from Pyrococcus horikoshii==
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<StructureSection load='2cyc' size='340' side='right'caption='[[2cyc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of Tyrosyl-tRNA Synthetase complexed with L-tyrosine from Pyrococcus horikoshii===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cyc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CYC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16325203}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyc OCA], [https://pdbe.org/2cyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cyc RCSB], [https://www.ebi.ac.uk/pdbsum/2cyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cyc ProSAT], [https://www.topsan.org/Proteins/RSGI/2cyc TOPSAN]</span></td></tr>
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[[2cyc]] is a 2 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYY_PYRHO SYY_PYRHO] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).[HAMAP-Rule:MF_02009]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cyc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cyc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016325203</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Kobayashi T]]
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[[Category: Kobayashi, T.]]
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[[Category: Kuratani M]]
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[[Category: Kuratani, M.]]
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[[Category: Sakai H]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sakamoto K]]
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[[Category: Sakai, H.]]
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[[Category: Sekine S]]
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[[Category: Sakamoto, K.]]
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[[Category: Shirouzu M]]
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[[Category: Sekine, S.]]
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[[Category: Takahashi M]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Takahashi, M.]]
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[[Category: Yanagisawa T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yanagisawa, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: Aminoacylation]]
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[[Category: Ligase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tyrosine]]
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[[Category: Tyrr]]
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Current revision

Crystal structure of Tyrosyl-tRNA Synthetase complexed with L-tyrosine from Pyrococcus horikoshii

PDB ID 2cyc

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