1qko

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:47, 13 December 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1qko.png|left|200px]]
 
-
{{STRUCTURE_1qko| PDB=1qko | SCENE= }}
+
==HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE==
 +
<StructureSection load='1qko' size='340' side='right'caption='[[1qko]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1qko]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QKO FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qko OCA], [https://pdbe.org/1qko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qko RCSB], [https://www.ebi.ac.uk/pdbsum/1qko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qko ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BACR_HALSA BACR_HALSA] Light-driven proton pump.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/1qko_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qko ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Bacteriorhodopsin is the simplest known photon-driven proton pump and as such provides a model for the study of a basic function in bioenergetics. Its seven transmembrane helices encompass a proton translocation pathway containing the chromophore, a retinal molecule covalently bound to lysine 216 through a protonated Schiff base, and a series of proton donors and acceptors. Photoisomerization of the all-trans retinal to the 13-cis configuration initiates the vectorial translocation of a proton from the Schiff base, the primary proton donor, to the extracellular side, followed by reprotonation of the Schiff base from the cytoplasm. Here we describe the high-resolution X-ray structure of an early intermediate in the photocycle of bacteriorhodopsin, which is formed directly after photoexcitation. A key water molecule is dislocated, allowing the primary proton acceptor, Asp 85, to move. Movement of the main-chain Lys 216 locally disrupts the hydrogen-bonding network of helix G, facilitating structural changes later in the photocycle.
-
===HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE===
+
High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle.,Edman K, Nollert P, Royant A, Belrhali H, Pebay-Peyroula E, Hajdu J, Neutze R, Landau EM Nature. 1999 Oct 21;401(6755):822-6. PMID:10548112<ref>PMID:10548112</ref>
-
{{ABSTRACT_PUBMED_10548112}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1qko" style="background-color:#fffaf0;"></div>
-
[[1qko]] is a 1 chain structure of [[Bacteriorhodopsin]] with sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKO OCA].
+
==See Also==
==See Also==
-
*[[Bacteriorhodopsin|Bacteriorhodopsin]]
+
*[[Bacteriorhodopsin 3D structures|Bacteriorhodopsin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:010548112</ref><ref group="xtra">PMID:010467143</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Halobacterium salinarum]]
[[Category: Halobacterium salinarum]]
-
[[Category: Belrhali, H.]]
+
[[Category: Large Structures]]
-
[[Category: Edman, K.]]
+
[[Category: Belrhali H]]
-
[[Category: Hajdu, J.]]
+
[[Category: Edman K]]
-
[[Category: Landau, E M.]]
+
[[Category: Hajdu J]]
-
[[Category: Neutze, R.]]
+
[[Category: Landau EM]]
-
[[Category: Nollert, P.]]
+
[[Category: Neutze R]]
-
[[Category: Pebay-Peyroula, E.]]
+
[[Category: Nollert P]]
-
[[Category: Royant, A.]]
+
[[Category: Pebay-Peyroula E]]
-
[[Category: Intermediate state]]
+
[[Category: Royant A]]
-
[[Category: Lipidic cubic phase]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Photocycle]]
+
-
[[Category: Photoreceptor]]
+
-
[[Category: Proton pump]]
+
-
[[Category: Retinal protein]]
+

Current revision

HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE

PDB ID 1qko

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qko"
Personal tools