1lca

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:31, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1lca.png|left|200px]]
 
-
{{STRUCTURE_1lca| PDB=1lca | SCENE= }}
+
==LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717==
-
 
+
<StructureSection load='1lca' size='340' side='right'caption='[[1lca]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
===LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1lca]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LCA FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_8371269}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lca OCA], [https://pdbe.org/1lca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lca RCSB], [https://www.ebi.ac.uk/pdbsum/1lca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lca ProSAT]</span></td></tr>
-
[[1lca]] is a 1 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LCA OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lc/1lca_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lca ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Thymidylate synthase|Thymidylate synthase]]
+
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:008371269</ref><references group="xtra"/>
+
[[Category: Lacticaseibacillus casei]]
-
[[Category: Lactobacillus casei]]
+
[[Category: Large Structures]]
-
[[Category: Thymidylate synthase]]
+
[[Category: Birdsall DL]]
-
[[Category: Birdsall, D L.]]
+
[[Category: Finer-Moore J]]
-
[[Category: Finer-Moore, J.]]
+
[[Category: Stroud RM]]
-
[[Category: Stroud, R M.]]
+
-
[[Category: Nucleotide synthase]]
+

Current revision

LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717

PDB ID 1lca

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lca"
Personal tools