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1n4k

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[[Image:1n4k.png|left|200px]]
 
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{{STRUCTURE_1n4k| PDB=1n4k | SCENE= }}
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==Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3==
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<StructureSection load='1n4k' size='340' side='right'caption='[[1n4k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4K FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12442173}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [https://pdbe.org/1n4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [https://www.ebi.ac.uk/pdbsum/1n4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4k ProSAT]</span></td></tr>
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[[1n4k]] is a 1 chain structure of [[Inositol 1%2C4%2C5-Trisphosphate Receptor]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4k ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012442173</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Alattia, J R.]]
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[[Category: Alattia JR]]
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[[Category: Bosanac, I.]]
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[[Category: Bosanac I]]
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[[Category: Chan, J.]]
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[[Category: Chan J]]
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[[Category: Furuichi, T.]]
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[[Category: Furuichi T]]
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[[Category: Ikura, M.]]
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[[Category: Ikura M]]
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[[Category: Iwai, M.]]
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[[Category: Iwai M]]
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[[Category: Mal, T K.]]
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[[Category: Mal TK]]
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[[Category: Michikawa, T.]]
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[[Category: Michikawa T]]
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[[Category: Mikoshiba, K.]]
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[[Category: Mikoshiba K]]
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[[Category: Talarico, S.]]
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[[Category: Talarico S]]
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[[Category: Tong, F K.]]
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[[Category: Tong FK]]
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[[Category: Tong, K I.]]
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[[Category: Tong KI]]
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[[Category: Yoshikawa, F.]]
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[[Category: Yoshikawa F]]
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[[Category: Armadillo-like fold]]
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[[Category: B-trefoil fold]]
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[[Category: Calcium channel]]
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[[Category: Ip3 receptor]]
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[[Category: Ip3-binding core]]
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[[Category: Membrane protein]]
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[[Category: Protein-ligand complex]]
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Current revision

Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3

PDB ID 1n4k

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