2f3k

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[[Image:2f3k.png|left|200px]]
 
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{{STRUCTURE_2f3k| PDB=2f3k | SCENE= }}
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==Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease==
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<StructureSection load='2f3k' size='340' side='right'caption='[[2f3k]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2f3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.599&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RO1:(3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE'>RO1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3k OCA], [https://pdbe.org/2f3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3k RCSB], [https://www.ebi.ac.uk/pdbsum/2f3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O38708_9HIV1 O38708_9HIV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f3k ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns.
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===Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease===
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Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.,Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:16569872<ref>PMID:16569872</ref>
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{{ABSTRACT_PUBMED_16569872}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2f3k" style="background-color:#fffaf0;"></div>
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[[2f3k]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3K OCA].
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==See Also==
==See Also==
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*[[Virus protease|Virus protease]]
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016569872</ref><references group="xtra"/>
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__TOC__
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[[Category: HIV-1 retropepsin]]
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</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Cammack, N.]]
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[[Category: Large Structures]]
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[[Category: Heilek-Snyder, G.]]
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[[Category: Cammack N]]
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[[Category: King, N M.]]
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[[Category: Heilek-Snyder G]]
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[[Category: Nalivaika, E A.]]
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[[Category: King NM]]
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[[Category: Prabu-Jeyabalan, M.]]
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[[Category: Nalivaika EA]]
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[[Category: Schiffer, C A.]]
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[[Category: Prabu-Jeyabalan M]]
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[[Category: Drug resistance]]
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[[Category: Schiffer CA]]
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[[Category: Hiv protease]]
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[[Category: Hydrolase]]
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[[Category: Ro1]]
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[[Category: Substrate envelope]]
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Current revision

Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease

PDB ID 2f3k

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