1vp3

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[[Image:1vp3.png|left|200px]]
 
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{{STRUCTURE_1vp3| PDB=1vp3 | SCENE= }}
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==VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE==
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<StructureSection load='1vp3' size='340' side='right'caption='[[1vp3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1vp3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VP3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vp3 OCA], [https://pdbe.org/1vp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vp3 RCSB], [https://www.ebi.ac.uk/pdbsum/1vp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vp3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCE_VACCW MCE_VACCW] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.<ref>PMID:1313572</ref> <ref>PMID:1670500</ref> <ref>PMID:12359447</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/1vp3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vp3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.
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===VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE===
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Specific protein recognition of an mRNA cap through its alkylated base.,Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA Nat Struct Biol. 1997 May;4(5):350-4. PMID:9145102<ref>PMID:9145102</ref>
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{{ABSTRACT_PUBMED_9145102}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1vp3" style="background-color:#fffaf0;"></div>
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[[1vp3]] is a 1 chain structure of [[Poly(A) Polymerase]] with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VP3 OCA].
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==See Also==
==See Also==
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*[[Poly(A) Polymerase|Poly(A) Polymerase]]
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*[[Poly(A) polymerase 3D structures|Poly(A) polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009145102</ref><references group="xtra"/>
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__TOC__
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[[Category: Polynucleotide adenylyltransferase]]
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</StructureSection>
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[[Category: Vaccinia virus]]
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[[Category: Large Structures]]
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[[Category: Gershon, P D.]]
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[[Category: Vaccinia virus WR]]
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[[Category: Hodel, A E.]]
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[[Category: Gershon PD]]
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[[Category: Quiocho, F A.]]
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[[Category: Hodel AE]]
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[[Category: Methyltransferase]]
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[[Category: Quiocho FA]]
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[[Category: Mrna processing]]
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[[Category: Rna cap]]
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[[Category: Transcription]]
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[[Category: Vaccinia]]
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Current revision

VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE

PDB ID 1vp3

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