2b9z
From Proteopedia
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| - | [[Image:2b9z.png|left|200px]] | ||
| - | + | ==Solution structure of FHV B2, a viral suppressor of RNAi== | |
| + | <StructureSection load='2b9z' size='340' side='right'caption='[[2b9z]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2b9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9z OCA], [https://pdbe.org/2b9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b9z RCSB], [https://www.ebi.ac.uk/pdbsum/2b9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2_FHV B2_FHV] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:14745017</ref> <ref>PMID:16228003</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms an elongated binding interface with double-stranded RNA (dsRNA). This implies a novel mode of dsRNA recognition and provides insights into the mechanism of RNAi suppression by B2. | ||
| - | + | The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.,Lingel A, Simon B, Izaurralde E, Sattler M EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100<ref>PMID:16270100</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2b9z" style="background-color:#fffaf0;"></div> | |
| - | + | ||
==See Also== | ==See Also== | ||
| - | *[[Flock house virus | + | *[[Flock house virus protein B2|Flock house virus protein B2]] |
| - | *[[ | + | *[[P19|P19]] |
*[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]] | *[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]] | ||
*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]] | *[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: Flock | + | </StructureSection> |
| - | [[Category: Izaurralde | + | [[Category: Flock House virus]] |
| - | [[Category: Lingel | + | [[Category: Large Structures]] |
| - | [[Category: Sattler | + | [[Category: Izaurralde E]] |
| - | [[Category: Simon | + | [[Category: Lingel A]] |
| - | + | [[Category: Sattler M]] | |
| - | + | [[Category: Simon B]] | |
| - | + | ||
Current revision
Solution structure of FHV B2, a viral suppressor of RNAi
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