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1rzt

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[[Image:1rzt.png|left|200px]]
 
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{{STRUCTURE_1rzt| PDB=1rzt | SCENE= }}
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==Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule==
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<StructureSection load='1rzt' size='340' side='right'caption='[[1rzt]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rzt]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZT FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14992725}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzt OCA], [https://pdbe.org/1rzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rzt RCSB], [https://www.ebi.ac.uk/pdbsum/1rzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rzt ProSAT]</span></td></tr>
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[[1rzt]] is a 16 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZT OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rzt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rzt ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014992725</ref><references group="xtra"/>
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__TOC__
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[[Category: DNA-directed DNA polymerase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bebenek, K.]]
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[[Category: Large Structures]]
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[[Category: Blanco, L.]]
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[[Category: Bebenek K]]
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[[Category: Garcia-Diaz, M.]]
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[[Category: Blanco L]]
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[[Category: Krahn, J M.]]
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[[Category: Garcia-Diaz M]]
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[[Category: Kunkel, T A.]]
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[[Category: Krahn JM]]
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[[Category: Pedersen, L C.]]
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[[Category: Kunkel TA]]
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[[Category: Dna polymerase lambda]]
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[[Category: Pedersen LC]]
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[[Category: Transferase-dna complex]]
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Current revision

Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule

PDB ID 1rzt

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