1apc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:26, 13 March 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1apc.gif|left|200px]]<br /><applet load="1apc" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1apc" />
 
-
'''SOLUTION STRUCTURE OF APOCYTOCHROME B562'''<br />
 
-
==Overview==
+
==SOLUTION STRUCTURE OF APOCYTOCHROME B562==
-
The apoprotein is an important intermediate on the folding pathways of many haem proteins, yet a detailed structure of such an intermediate has remained elusive. Here we present the structure of apocytochrome b562 obtained by NMR spectroscopy. The apoprotein has a topology similar to the holoprotein. Nevertheless, significant differences in helix-helix packing between the two are evident. Much of the haem binding pocket in the apoprotein is preserved but exposed to solvent creating a large cavern. As apocytochrome b562 displays many of the physical characteristics ascribed to the molten globule state, these results help ellucidate the origin of several properties of the protein molten globule.
+
<StructureSection load='1apc' size='340' side='right'caption='[[1apc]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1apc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1APC FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1apc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apc OCA], [https://pdbe.org/1apc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1apc RCSB], [https://www.ebi.ac.uk/pdbsum/1apc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1apc ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/1apc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1apc ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1APC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APC OCA].
+
*[[Cytochrome b5 3D structures|Cytochrome b5 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Solution structure of apocytochrome b562., Feng Y, Sligar SG, Wand AJ, Nat Struct Biol. 1994 Jan;1(1):30-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7656004 7656004]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Feng, Y.]]
+
[[Category: Feng Y]]
-
[[Category: Sligar, S G.]]
+
[[Category: Sligar SG]]
-
[[Category: Wand, A J.]]
+
[[Category: Wand AJ]]
-
[[Category: electron transport]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:57 2008''
+

Current revision

SOLUTION STRUCTURE OF APOCYTOCHROME B562

PDB ID 1apc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1apc"
Personal tools