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1x81

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[[Image:1x81.png|left|200px]]
 
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{{STRUCTURE_1x81| PDB=1x81 | SCENE= }}
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==Farnesyl transferase structure of Jansen compound==
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<StructureSection load='1x81' size='340' side='right'caption='[[1x81]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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===Farnesyl transferase structure of Jansen compound===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X81 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15454228}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JAN:6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE'>JAN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x81 OCA], [https://pdbe.org/1x81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x81 RCSB], [https://www.ebi.ac.uk/pdbsum/1x81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x81 ProSAT]</span></td></tr>
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[[1x81]] is a 2 chain structure of [[Farnesyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X81 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/1x81_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x81 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Farnesyltransferase|Farnesyltransferase]]
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*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015454228</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Protein farnesyltransferase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Claiborne, A.]]
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[[Category: Claiborne A]]
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[[Category: Cohen, J.]]
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[[Category: Cohen J]]
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[[Category: Frost, D.]]
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[[Category: Frost D]]
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[[Category: Gu, W.]]
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[[Category: Gu W]]
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[[Category: Hasvold, L.]]
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[[Category: Hasvold L]]
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[[Category: Hutchins, C.]]
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[[Category: Hutchins C]]
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[[Category: Jakob, C G.]]
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[[Category: Jakob CG]]
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[[Category: Li, Q.]]
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[[Category: Li Q]]
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[[Category: Li, T.]]
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[[Category: Li T]]
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[[Category: Muchmore, S.]]
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[[Category: Muchmore S]]
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[[Category: Rosenberg, S H.]]
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[[Category: Rosenberg SH]]
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[[Category: Sham, H L.]]
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[[Category: Sham HL]]
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[[Category: Stoll, V S.]]
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[[Category: Stoll VS]]
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[[Category: Fanesyltransferase]]
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[[Category: Transferase]]
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Current revision

Farnesyl transferase structure of Jansen compound

PDB ID 1x81

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