3k2q

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[[Image:3k2q.png|left|200px]]
 
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{{STRUCTURE_3k2q| PDB=3k2q | SCENE= }}
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==Crystal structure of Pyrophosphate-dependent phosphofructokinase from Marinobacter aquaeolei, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MqR88==
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<StructureSection load='3k2q' size='340' side='right'caption='[[3k2q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of Pyrophosphate-dependent phosphofructokinase from Marinobacter aquaeolei, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MqR88===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3k2q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Marinobacter_nauticus_VT8 Marinobacter nauticus VT8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K2Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[3k2q]] is a 3 chain structure of [[Phosphofructokinase (PFK)]] with sequence from [http://en.wikipedia.org/wiki/Marinobacter_aquaeolei_vt8 Marinobacter aquaeolei vt8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2Q OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2q OCA], [https://pdbe.org/3k2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k2q RCSB], [https://www.ebi.ac.uk/pdbsum/3k2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k2q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A1U3A9_MARN8 A1U3A9_MARN8] Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.[HAMAP-Rule:MF_01978]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/3k2q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k2q ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphofructokinase (PFK)|Phosphofructokinase (PFK)]]
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*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
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[[Category: Diphosphate--fructose-6-phosphate 1-phosphotransferase]]
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__TOC__
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[[Category: Marinobacter aquaeolei vt8]]
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</StructureSection>
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Baran, M C.]]
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[[Category: Marinobacter nauticus VT8]]
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[[Category: Cunningham, K.]]
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[[Category: Acton TB]]
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[[Category: Hunt, J F.]]
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[[Category: Baran MC]]
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[[Category: Janjua, K.]]
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[[Category: Cunningham K]]
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[[Category: Lew, S.]]
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[[Category: Hunt JF]]
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[[Category: Liu, J.]]
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[[Category: Janjua K]]
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[[Category: Montelione, G T.]]
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[[Category: Lew S]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Liu J]]
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[[Category: Neely, H.]]
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[[Category: Montelione GT]]
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[[Category: Owens, L.]]
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[[Category: Neely H]]
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[[Category: Rost, B.]]
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[[Category: Owens L]]
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[[Category: Seetharaman, J.]]
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[[Category: Rost B]]
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[[Category: Tong, L.]]
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[[Category: Seetharaman J]]
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[[Category: Wang, D.]]
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[[Category: Tong L]]
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[[Category: Xiao, R.]]
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[[Category: Wang D]]
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[[Category: Kinase]]
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[[Category: Xiao R]]
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[[Category: Kinase transferase]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Pyrophosphate-dependent phosphofructokinase]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Pyrophosphate-dependent phosphofructokinase from Marinobacter aquaeolei, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MqR88

PDB ID 3k2q

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