3otp

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[[Image:3otp.png|left|200px]]
 
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{{STRUCTURE_3otp| PDB=3otp | SCENE= }}
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==Crystal structure of the DegP dodecamer with a model substrate==
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<StructureSection load='3otp' size='340' side='right'caption='[[3otp]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
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===Crystal structure of the DegP dodecamer with a model substrate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3otp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OTP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21458668}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.76&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3otp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3otp OCA], [https://pdbe.org/3otp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3otp RCSB], [https://www.ebi.ac.uk/pdbsum/3otp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3otp ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3otp]] is a 12 chain structure of [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTP OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>
==See Also==
==See Also==
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*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:021458668</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Grant, R A.]]
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[[Category: Grant RA]]
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[[Category: Kim, S.]]
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[[Category: Kim S]]
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[[Category: Sauer, R T.]]
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[[Category: Sauer RT]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Typsin-like protease domain pdz domain]]
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Current revision

Crystal structure of the DegP dodecamer with a model substrate

PDB ID 3otp

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