2ouq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:06, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ouq.png|left|200px]]
 
-
{{STRUCTURE_2ouq| PDB=2ouq | SCENE= }}
+
==crystal structure of PDE10A2 in complex with GMP==
-
 
+
<StructureSection load='2ouq' size='340' side='right'caption='[[2ouq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
===crystal structure of PDE10A2 in complex with GMP===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2ouq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OUQ FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_17389385}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ouq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ouq OCA], [https://pdbe.org/2ouq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ouq RCSB], [https://www.ebi.ac.uk/pdbsum/2ouq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ouq ProSAT]</span></td></tr>
-
[[2ouq]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUQ OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/2ouq_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ouq ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Phosphodiesterase|Phosphodiesterase]]
+
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:017389385</ref><references group="xtra"/>
+
__TOC__
-
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Hou, J.]]
+
[[Category: Large Structures]]
-
[[Category: Liu, Y D.]]
+
[[Category: Hou J]]
-
[[Category: Robinson, H.]]
+
[[Category: Liu YD]]
-
[[Category: Wang, H C.]]
+
[[Category: Robinson H]]
-
[[Category: Zheng, M Y.]]
+
[[Category: Wang HC]]
-
[[Category: Gmp complex]]
+
[[Category: Zheng MY]]
-
[[Category: Hydrolase]]
+
-
[[Category: Pde]]
+

Current revision

crystal structure of PDE10A2 in complex with GMP

PDB ID 2ouq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ouq"
Personal tools