2dfe

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[[Image:2dfe.png|left|200px]]
 
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{{STRUCTURE_2dfe| PDB=2dfe | SCENE= }}
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==Crystal structure of Tk-RNase HII(1-200)-C==
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<StructureSection load='2dfe' size='340' side='right'caption='[[2dfe]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DFE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dfe OCA], [https://pdbe.org/2dfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dfe RCSB], [https://www.ebi.ac.uk/pdbsum/2dfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dfe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNH2_THEKO RNH2_THEKO] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/2dfe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dfe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Certain sequences, known as chameleon sequences, take both alpha- and beta-conformations in natural proteins. We demonstrate that a wild chameleon sequence fused to the C-terminal alpha-helix or beta-sheet in foreign stable proteins from hyperthermophiles forms the same conformation as the host secondary structure. However, no secondary structural formation is observed when the sequence is attached to the outside of the secondary structure. These results indicate that this sequence inherently possesses an ability to make either alpha- or beta-conformation, depending on the sequentially neighboring secondary structure if little other nonlocal interaction occurs. Thus, chameleon sequences take on a satellite state through contagion by the power of a secondary structure. We propose this "conformational contagion" as a new nonlocal determinant factor in protein structure and misfolding related to protein conformational diseases.
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===Crystal structure of Tk-RNase HII(1-200)-C===
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Conformational contagion in a protein: structural properties of a chameleon sequence.,Takano K, Katagiri Y, Mukaiyama A, Chon H, Matsumura H, Koga Y, Kanaya S Proteins. 2007 Aug 15;68(3):617-25. PMID:17510955<ref>PMID:17510955</ref>
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{{ABSTRACT_PUBMED_17510955}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2dfe" style="background-color:#fffaf0;"></div>
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[[2dfe]] is a 1 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Thermococcus_kodakarensis Thermococcus kodakarensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DFE OCA].
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==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017510955</ref><references group="xtra"/>
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__TOC__
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[[Category: Ribonuclease H]]
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</StructureSection>
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[[Category: Thermococcus kodakarensis]]
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[[Category: Large Structures]]
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[[Category: Chon, H.]]
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[[Category: Thermococcus kodakarensis KOD1]]
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[[Category: Kanaya, S.]]
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[[Category: Chon H]]
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[[Category: Katagiri, Y.]]
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[[Category: Kanaya S]]
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[[Category: Koga, Y.]]
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[[Category: Katagiri Y]]
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[[Category: Matsumura, H.]]
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[[Category: Koga Y]]
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[[Category: Takano, K.]]
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[[Category: Matsumura H]]
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[[Category: Chameleon sequence]]
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[[Category: Takano K]]
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[[Category: Fusion protein]]
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[[Category: Hydrolase]]
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[[Category: Ribonuclease hii]]
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[[Category: Thermococcus kodakaraensis]]
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Current revision

Crystal structure of Tk-RNase HII(1-200)-C

PDB ID 2dfe

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