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1qrp

From Proteopedia

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[[Image:1qrp.png|left|200px]]
 
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{{STRUCTURE_1qrp| PDB=1qrp | SCENE= }}
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==Human pepsin 3A in complex with a phosphonate inhibitor IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME==
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<StructureSection load='1qrp' size='340' side='right'caption='[[1qrp]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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===Human pepsin 3A in complex with a phosphonate inhibitor IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QRP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10713513}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HH0:METHYL+N-[(2S)-2-({(S)-HYDROXY[(1R)-3-METHYL-1-{[N-(3-METHYLBUTANOYL)-L-VALYL-L-VALYL]AMINO}BUTYL]PHOSPHORYL}OXY)-3-PHENYLPROPANOYL]-L-ALANYL-L-ALANINATE'>HH0</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qrp OCA], [https://pdbe.org/1qrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qrp RCSB], [https://www.ebi.ac.uk/pdbsum/1qrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qrp ProSAT]</span></td></tr>
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[[1qrp]] is a 1 chain structure of [[Pepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PEPA4_HUMAN PEPA4_HUMAN] Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qrp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qrp ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Pepsin|Pepsin]]
*[[Pepsin|Pepsin]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010713513</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bartlett, P A.]]
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[[Category: Large Structures]]
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[[Category: Cherney, M M.]]
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[[Category: Bartlett PA]]
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[[Category: Fujinaga, M.]]
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[[Category: Cherney MM]]
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[[Category: Hanson, J E.]]
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[[Category: Fujinaga M]]
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[[Category: James, M N.G.]]
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[[Category: Hanson JE]]
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[[Category: Tarasova, N I.]]
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[[Category: James MNG]]
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[[Category: Aspartic proteinase]]
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[[Category: Tarasova NI]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Phosphonate inhibitor]]
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[[Category: Transition state analogue]]
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Current revision

Human pepsin 3A in complex with a phosphonate inhibitor IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME

PDB ID 1qrp

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