1avc

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[[Image:1avc.gif|left|200px]]<br /><applet load="1avc" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1avc, resolution 2.90&Aring;" />
 
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'''BOVINE ANNEXIN VI (CALCIUM-BOUND)'''<br />
 
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==Overview==
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==BOVINE ANNEXIN VI (CALCIUM-BOUND)==
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<StructureSection load='1avc' size='340' side='right'caption='[[1avc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1avc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AVC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1avc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1avc OCA], [https://pdbe.org/1avc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1avc RCSB], [https://www.ebi.ac.uk/pdbsum/1avc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1avc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANXA6_BOVIN ANXA6_BOVIN] May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/1avc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1avc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
The crystal structure of a calcium-bound form of bovine annexin VI has been determined with X-ray diffraction data to 2.9 A by molecular replacement. Six Ca2+ ions were found, five in AB loops, one in a DE loop. Two loops (II-AB, which binds calcium, and V-AB, which does not) have conformations that differ significantly from those in calcium-free, human recombinant annexin VI. There are only small differences between the calci- and the apo-annexin VI in the rest of the molecule. Calcium by itself does not promote a major conformational change.
The crystal structure of a calcium-bound form of bovine annexin VI has been determined with X-ray diffraction data to 2.9 A by molecular replacement. Six Ca2+ ions were found, five in AB loops, one in a DE loop. Two loops (II-AB, which binds calcium, and V-AB, which does not) have conformations that differ significantly from those in calcium-free, human recombinant annexin VI. There are only small differences between the calci- and the apo-annexin VI in the rest of the molecule. Calcium by itself does not promote a major conformational change.
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==About this Structure==
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Crystal structure of bovine annexin VI in a calcium-bound state.,Avila-Sakar AJ, Creutz CE, Kretsinger RH Biochim Biophys Acta. 1998 Sep 8;1387(1-2):103-16. PMID:9748523<ref>PMID:9748523</ref>
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1AVC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVC OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of bovine annexin VI in a calcium-bound state., Avila-Sakar AJ, Creutz CE, Kretsinger RH, Biochim Biophys Acta. 1998 Sep 8;1387(1-2):103-16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9748523 9748523]
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</div>
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[[Category: Bos taurus]]
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<div class="pdbe-citations 1avc" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Avila-Sakar, A J.]]
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[[Category: Creutz, C E.]]
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[[Category: Kretsinger, R H.]]
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[[Category: CA]]
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[[Category: annexin]]
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[[Category: calcium-binding]]
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[[Category: calcium/phospholipid-binding protein]]
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[[Category: membrane-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:39 2008''
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==See Also==
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*[[Annexin 3D structures|Annexin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Large Structures]]
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[[Category: Avila-Sakar AJ]]
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[[Category: Creutz CE]]
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[[Category: Kretsinger RH]]

Current revision

BOVINE ANNEXIN VI (CALCIUM-BOUND)

PDB ID 1avc

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