1n2d

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[[Image:1n2d.png|left|200px]]
 
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{{STRUCTURE_1n2d| PDB=1n2d | SCENE= }}
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==Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin==
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<StructureSection load='1n2d' size='340' side='right'caption='[[1n2d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n2d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N2D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16120677}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n2d OCA], [https://pdbe.org/1n2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n2d RCSB], [https://www.ebi.ac.uk/pdbsum/1n2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n2d ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1n2d]] is a 3 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N2D OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/MLC1_YEAST MLC1_YEAST] Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.<ref>PMID:9700160</ref> <ref>PMID:12456647</ref> <ref>PMID:15210731</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n2/1n2d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n2d ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016120677</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Dominguez, R.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Lu, R C.]]
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[[Category: Dominguez R]]
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[[Category: Stafford, W F.]]
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[[Category: Lu RC]]
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[[Category: Terrak, M.]]
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[[Category: Stafford WF]]
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[[Category: Wu, G.]]
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[[Category: Terrak M]]
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[[Category: Cell cycle]]
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[[Category: Wu G]]
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[[Category: Iq motif]]
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[[Category: Myosin light chain]]
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[[Category: Protein-peptide complex]]
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Current revision

Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin

PDB ID 1n2d

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