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3owd
From Proteopedia
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| - | [[Image:3owd.png|left|200px]] | ||
| - | + | ==Crystal Structure of HSP90 with N-Aryl-benzimidazolone II== | |
| - | + | <StructureSection load='3owd' size='340' side='right'caption='[[3owd]], [[Resolution|resolution]] 1.63Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3owd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MEY:N-{[1-(5-CHLORO-2,4-DIHYDROXYPHENYL)-2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOL-5-YL]METHYL}NAPHTHALENE-1-SULFONAMIDE'>MEY</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owd OCA], [https://pdbe.org/3owd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owd RCSB], [https://www.ebi.ac.uk/pdbsum/3owd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owd ProSAT]</span></td></tr> |
| - | [[3owd]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Heat Shock | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Park CH]] |
| - | + | ||
Current revision
Crystal Structure of HSP90 with N-Aryl-benzimidazolone II
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