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3hd4
From Proteopedia
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| - | [[Image:3hd4.png|left|200px]] | ||
| - | + | ==MHV Nucleocapsid Protein NTD== | |
| - | + | <StructureSection load='3hd4' size='340' side='right'caption='[[3hd4]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3hd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_hepatitis_virus_strain_A59 Murine hepatitis virus strain A59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HD4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.747Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hd4 OCA], [https://pdbe.org/3hd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hd4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hd4 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[3hd4]] is a 1 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/NCAP_CVMA5 NCAP_CVMA5] Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication. Induces transcription of the prothrombinase (FGL2) and elevates procoagulant activity.<ref>PMID:12594208</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/3hd4_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hd4 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Nucleoprotein|Nucleoprotein]] | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Murine hepatitis virus strain A59]] |
| - | [[Category: | + | [[Category: Dann III CE]] |
| - | [[Category: | + | [[Category: Giedroc DP]] |
| - | + | [[Category: Keane SC]] | |
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Current revision
MHV Nucleocapsid Protein NTD
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